Reformation had its beginning in a meeting of Lutherans in the home of Mr. and Mrs. Fred C. Park on October 17, 1951. The Rev. Karl W. Kinard, D.D., President of the SC Synod, and the Rev. J. Shelton Moose (Pastor of St. Timothy's Lutheran Church, Camden, SC), met with them to plan the first service, which was held on Reformation Sunday (October 28, 1951) in the First Presbyterian Church of Lancaster. Pastor Moose served as Mission Developer and part-time pastor until 1954. The official organizational service was held on Reformation Sunday (November 1, 1953) in the First Methodist Church of Lancaster—with 54 confirmed members and 78 baptized members. 

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In light of the first service being held on Reformation Sunday and the official organizational service being held on Reformation Sunday, no name was more appropriate than "Reformation Lutheran Church". 

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A ground breaking service for a church building on the corner of French and Springs Streets was held on April 15, 1956. The first service was held in the new church building on December 2, 1956. Up until that time, services were held at the Lancaster County Health Department building. 

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In 2023, Reformation celebrated its 70th anniversary.